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Neuronal response to oxidative stress may activate GSK3, leading to the redirection of membrane-bound APP into the pro-amyloidogenic pathway (see Section Unlocking Melatonins Anti-Amyloidogenic Potential and Fig

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The most commonly reported adverse effects in the trial were gastrointestinal in nature including nausea, diarrhoea, vomiting, and constipation which is consistent with the broader GLP-1 receptor agonist class

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